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Year : 2021  |  Volume : 4  |  Issue : 2  |  Page : 59-66

Standardization of Rasagandhi mezhugu: A traditional siddha higher order herbomineral formulation

1 Central Council for Research in Siddha (CCRS), Chennai, Tamil Nadu, India
2 Siddha Regional Research Institute, Central Council for Research in Siddha (CCRS), Poojapura, Kerala, India
3 Siddha Central Research Institute (SCRI), Central Council for Research in Siddha (CCRS), Chennai, Tamil Nadu, India

Correspondence Address:
Dr. Viswan Lilly Reena
Siddha Regional Research Institute, Poojapura P.O., Thiruvananthapuram - 695 012, Kerala
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jrsm.jrsm_11_22

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Background: Rasagandhi mezhugu (RGM) is the higher order Siddha formulation comprising of mercury, arsenical compounds, minerals and herbs and is indicated for chronic diseases like Megarogam, Kiranthi, Puttrunoi, etc. Objectives: The objective of the present investigation was to standardize the formulation of RGM. Materials and Methods: The organoleptic characters such as color, appearance, taste, and odor were noted. RGM was screened for moisture content, total ash value, water-soluble ash, acid-insoluble ash, alcohol-soluble extractive value, water-soluble extractive value, microbial load, and specific pathogen to estimate the quality of the study drug. Results: The outcomes of the physiochemical analysis of RGM were found to be within standard limits. RGM is free from specific pathogens such as Escherichia coli, Salmonella, Pseudomonas, and Staphylococcus aureus. The overall safety regarding heavy-metal content was assured by quantifying the metal content using inductively coupled plasma optical emission spectroscopy. The high-performance thin-layer chromatography fingerprint of RGM was generated. Conclusion: The results attained from the study could be used as a reference for setting limits for the quality assurance and quality control of Rasagandhi mezhugu.

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