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 Table of Contents  
REVIEW ARTICLE
Year : 2021  |  Volume : 4  |  Issue : 2  |  Page : 46-53

An overview on Siddha treatment guideline for diabetes mellitus: a non-communicable disease


Siddha Central Research Institute, Central Council for Research in Siddha, Arumbakkam, Chennai, Tamil Nadu, India

Date of Submission18-Apr-2022
Date of Acceptance06-Sep-2022
Date of Web Publication23-Jan-2023

Correspondence Address:
Dr. Panneerselvam Thenmozhi
Siddha Central Research Institute (Central Council for Research in Siddha, Ministry of AYUSH, Govt. of India), Anna Govt. Hospital Campus, Arumbakkam, Chennai - 600 106, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jrsm.jrsm_13_22

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  Abstract 

Diabetes mellitus is a heterogeneous metabolic disorder characterized by altered carbohydrate, lipid, and protein metabolism which causes hyperglycemia resulting from insufficient insulin secretion, insulin action, or both. The WHO projects that diabetes will be the seventh leading cause of death in 2030. Diabetes can be treated, and its consequences avoided or delayed with diet, physical activity, medication, and regular screening and treatment for complications. It has various synonyms (Verupeyar) in Siddha system of medicine such as Miguneer, VeguMoothiram, InippuNeer, MeghaNeer, and Madhumegham. The Siddha treatment guideline for diabetes discusses the following headings: Definition (Noi iyalbu), Synonyms (Veru peyar), Etiology (NoiVarum vazhi), Clinical features (Noi Kurikunangal), Disease classification (Noi Enn), Investigations (Ennvagai Thervu), Differential diagnosis, Humoral changes (Thirithoda Marupadugal), Management and treatment plan (Maruthuva Vazhimurai), Pharmacological treatment regimen, Non-pharmacological treatment regimen, Dietary regimen, Karpam, Varmam, Yogic practices, Prevention, Post-clinical care, and the single herbs used in the Siddha system of medicine which has a potent anti-diabetic, hypoglycemic activity.

Keywords: Diabetes mellitus, Madhumegham, Neerizhivu, Siddha, Thirithodam, treatment guideline


How to cite this article:
Thenmozhi P, Lavanya A, Kannan M, Shyamala R, Sathiyarajeswaran P. An overview on Siddha treatment guideline for diabetes mellitus: a non-communicable disease. J Res Siddha Med 2021;4:46-53

How to cite this URL:
Thenmozhi P, Lavanya A, Kannan M, Shyamala R, Sathiyarajeswaran P. An overview on Siddha treatment guideline for diabetes mellitus: a non-communicable disease. J Res Siddha Med [serial online] 2021 [cited 2023 Oct 2];4:46-53. Available from: http://www.jrsm.in/text.asp?2021/4/2/46/368439


  Introduction Top


Diabetes is a heterogeneous metabolic disorder characterized by altered carbohydrate, lipid, and protein metabolism, which causes hyperglycemia resulting from insufficient insulin secretion, insulin action, or both.[1] It is one of the refractory diseases identified by the Indian Council of Medical Research for which an alternative medicine is a need for the treatment. Diabetes mellitus has become a growing problem in the contemporary world. India has today become the diabetic capital of the world with over 20 million with diabetes, and this number is likely to increase to 57 million by 2025.[2]

The number of people with diabetes has risen from 108 million in 1980 to 422 million in 2014.[3] The global prevalence of diabetes among adults over 18 years of age has risen from 4.7% in 1980 to 8.5% in 2014.[3] Almost half of all deaths attributable to high blood glucose occur before the age of 70 years. The WHO projects that diabetes will be the seventh leading cause of death in 2030.[3] Healthy diet, regular physical activity, maintaining a normal body weight, and avoiding tobacco use are ways to prevent or delay the onset of type 2 diabetes. Diabetes can be treated, and its consequences avoided or delayed with diet, physical activity, medication, and regular screening and treatment for complications.

The Siddha treatment guideline for diabetes signifies the following headings: Definition (Noi iyalbu), Synonyms (Veru peyar), Etiology (NoiVarumvazhi), Clinical features (Noi Kurikunangal), Disease classification (Noi Enn), Investigations (Ennvagai Thervu), Differential diagnosis, Humoral changes (Thirithoda Marupadugal), Management–Treatment plan (Maruthuval Vazimurai), Pharmacological treatment regimen, Non-pharmacological treatment regimen, Dietary regimen, and single herbs used for the disease.


  Siddha Treatment Guideline For Diabetes Mellitus Top


Definition (Noi iyalbu)

It is a clinical condition characterized by frequent urination resulting in deterioration and diminution of seven thathus (body constituents) and loss of weight.

Synonyms (Veru peyar)

It has various synonyms (Verupeyar) in the Siddha system of medicine like Miguneer, VeguMoothiram, InippuNeer, MeghaNeer, and Madhumegham. The disease is caused due to improper diet such as excessive intake of mucilaginous and sweet taste foods, excessive sexual activity, stress, decreased physical activity, hereditary, and stimulation of Moolatharam by the other excited Vayus (Keelnokkunkal, Melnokkunkal, Paravukal).

Clinical features (Noi Kurikunangal)

The clinical features (Noikurikunangal) can be explained as follows: early stage: polyuria, polyphagia, polydipsia, loss of weight, insomnia, fatigue, giddiness, dyspnea, perspiration, dryness of the skin, and dryness of tongue; later stage: body weight decreases day by day and it leads to further complications and other related diseases.[4],[5]


  Classification of Diabetes Mellitus: Noienn Top
[4],[5]

In the Siddha system of medicine, diabetes mellitus is classified into Vali, Azhal, and Aiyam.

Vali 4: 1. Neimananeer, 2. Pasumananeer, 3. Seezhmananeer, 4. Sadhaimananeer;

Azhal 6:1. YanaikozhupuMananeer, 2. KatrazhaiMananeer, 3. ChunnaMananeer, 4. InnipuMegam, 5. PalinguNeer, 6. MuyalKuruthiNeer;

Aiyam 10: 1. Iyaneer, 2. Thuimaineer, 3. Moolaineer, 4. Ilaneer, 5. Ulneer, 6. Thavalaneer, 7. Kazhuneer, 8. Thenneer, 9. Uppuneer, 10. Kavichuneer.


  Invesigations (Envagaithervu) Top
[6],[7]

It is the method of disease diagnosis in Siddha. This includes the eight methods of physical examination of a patient. It consists of eight types of physical examination and is called “Envagai thervu.” These include: i. tongue (Naa), ii. color (Niram), iii. speech (Mozhi), iv. eyes (Vizhi), v. stool (Malam), vi. urine (Moothiram), vii. touch (Sparisam), and viii. pulse (Naadi). The investigations (Envagai Thervu) are given in [Table 1].
Table 1: Invesigations (EnvagaiThervu)

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  Humoral Pathogenesis: Mukkutra Verupadu Top
[5],[6],[7]

The body is balanced by the three humors, namely, Vali, Azhal, and Iyam, which has a direct relation with the five primordial elements and six tastes. Any derangement in these three humors results in the formation of disease. Derangement of this is the humoral pathology.

Based on the derangement and their relationship with the taste and pancha bhootham, the choice of drug is determined. Due to inherent and acquired activities, there is an imbalance in Aiyam. It does imply an imbalance in other two humors (Vali and Azhal) and causes derangement of Dasavayu and deterioration of seven Udalthathukkal (Udalthathukkal are the physical constituents, or the seven tissues viz. Saaram, Senneer, Oon, Konzhuppu, Enbu, Moolai and Sukkilam), which causes the disease and other complications.


  Management Of Neerizhivu (Diabetes Mellitus) Top


The aim of the treatment focusses mainly to restore the principally transformed humor. In diabetes mellitus, Vali, Azhal, and Aiyam are affected. An acquired and inherent cause increases the Aiyam that affects the other thathu. Avalambagam and kilethagam (types of Aiyam) get affected. The drug that decreases the Aiyam and that has a bitter and astringent taste is chosen to treat diabetes mellitus. Azhal gets decreased. Bio-combustion is challenged. There is a decrease in digestive fire and thus the body does not receive the nourishment from the food that leads to deterioration. AnarPithamm, RanjakaPitham, SadhagaPitham (types of Azhal) get affected. Drug that increases the digestive fire and the drug that has a bitter and astringent property are given.

Vali is decreased. Dasavayukkal (types of Vali) gets affected. Increased Aiyam and decreased Azhal affect the Vali. It leads to the further complications of the disease. The drugs that nourish the body constituents and prevent from further deterioration are chosen.


  Treatment Plan (Maruthuval Vazimurai) Top


Neerizhivu

Due to Aiyam type of physical constitution, sedentary lifestyle, increased intake of mucilaginous and sweet taste food, Azhal decreased and Aiyam is increased. The treatment plan for diabetes melitus (Neerizhivu) is depicted in [Figure 1].
Figure 1: Treatment plan for diabetes mellitus (Neerizhivu)

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  Pharmacological treatment Top


The treatment primarily aims

❖ To restore the affected Thathu (Vali, Azhal, Aiyam) and Vayukkal;

❖ To enrich the deteriorated seven body constituents;

❖ To prevent from further complications.


  PROCEDURE 1 Top


Therapeutic purgation

To restore the affected thathu, therapeutic purgation is given. One among the following medicines can be chosen based on the kutram (Vali, Azhal, Aiyam) affected: Sanjeevi Maathirai (100 mg)—1–2 tab. at early morning with white goat’s milk,[1] Agathiyar Kuzhambu—130 mg with 5 g of chukku karkam at early morning,[1] Meghanatha Thailam—8–30 mL early morning in empty stomach,[1] Merugulli Thailam—10–20 mL at early morning in empty stomach.[1]


  PROCEDURE 2 Top


The following are the list of medicines given related to the signs and symptoms of the patient for the management of diabetes mellitus. The choice of drugs to be chosen related to the (Ezhuudarkattukal) 7 body constituents affected [Table 2].
Table 2: Choice of drugs to be chosen related to the (Ezhuudarkattukal) seven body constituents affected

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  Non-Pharmacological Treatment Top


Dietary regimen[16],[22],[24]

The diet that nourishes and improves the seven body constituents is given and the diet that controls the excess excretion of urine is advised. Taste that can be added are spicy, astringent, and bitter. The taste that should be avoided are sweet, sour, and salt. Food pattern such as hot, light, spicy, dry food can be added. Cool, heavy, sweetened, soft, unctuous, and viscous food can be avoided.


  Diet—to Add Top


Grain and pulses: Gothumai, Samba Gothumai, Kezhvaragu, Thinai, Saamai, Mungilarasi, Milagusamba Rice, Mani Samba Rice, Karunsamba Rice, Kaikuthal Rice, Barley (Hordeum vulgare), Thuvarai (Cajanus cajan), Sirupayaru (Vigna mungo), Karumpayaru, Kondaikadalai, Kollu (V. unguiculeta). Greens: Vendhaya Keerai (Trigonella foenum-graecum), Keeraithandu (Amaranthus tricolor), Karivepillai, Arakeerai, Sirukeerai (A. tricolor), Kothamalli (Coriandrum sativum), Pudhina (Mentha arvensis), Pirandai, Vasalai, Kodivasalai (Basella alba), Puliyarai (Oxalis corniculata), Thoothuvalai (Solanum trilobatum), Allipoo, Sevalli poo (Nymphaea nouchali). Vegetables: Midhipagal (Momordica muricata), Kovai (Coccinia grandis), Sundai, Manathakkali (S. americanum), Katharai (S. melongena), Murungai (Moringa oleifera), Surai, Pudalangai (Trichosanthes cucumerina), Vellari (Cucumis sativus), Mullangi (Raphanus raphanistrum), Vidhaimudhiraavarai (Lablab purpureus), Vendai (Abelmoschus esculentus), onion (Allium cepa), tomato (S. lycopersicum), Maapinju (Mangifera indica), Karunaikizhangu, Vazhaipinju (Musa × paradisiaca), Pala Pinju (Artocarpus heterophyllus). Fruits: Naval (Syzygium cumini), Nelli (Phyllanthus emblica), Elumichai (Citrus limon), Koyya (Psidium guajava), Kovai (C. grandis), Madhulai (Punica granatum), Athipazham (Ficus racemosa), Doothalampazham, Peareetchangai (Phoenix dactylifera). Animal products: Nattukozhi, Kaanaankozhi, Kaadai, Kavuthari, Pallaiyattuiraitchi, Naattukozhimuttai, Vayalnandu, NaatupasuNei, Viral Meen. Nuts and seeds: Verkadalai (Cicer arietinum), Aalividhai (Linum usitatissimum), Dharpoosanividhai (Citrullus lanatus), Thulasividhai (Ocimum tenuiflorum), Poosanividhai (Benincasa hispida), Ellu, Badam Paruppu. Spices, salts, and sweetness: Vendhayam (T. foenum-graecum), Manjal (Curcuma longa), Chukku (Zingiber officinale), Inji (Z. officinale), Elam (Elettaria cardamomum), KurosaniOmam (Hyoscyamus niger), Lavangapattai, Seeragam (Cuminum cyminum), Milagu (Piper nigrum), Venmilagu (Piper nigrum), Perungayam (Narthex asafoetida), Jathipathiri (Myristica fragrans), Jathikkai (M. fragrans), Poondu (A. sativum), Kothamalli (C. sativum), Thirikadugu, Indhuppu. Then, Kasakasa, Patchaikarpooram, Kumkumapoo. Oils: sesame oil, gingelly oil. Drinks: Ilaneer (Cocos nucifera), butter milk, Neeragaram, KainthuaariyaNeer, MukkarpangukaindhuaariyaNeer, hot water stored in Panjaloga vatu and vellipaathiram, NavalverNeer, KarunkaliverNeer, IlavuverNeer, NannariverNeer (Hemidesmus indicus). Food: Freshly prepared warm food, Koogaikizhangu, Maa (Mangifera indica), ParuppuSadham.

Diet restrictions

Grain and pulse: Savvarisi, Ulundhu (Vigna radiata). Vegetables: starchy vegetables such as beets, carrots (Daucus carota), green peas (Pisum sativum), plantain, sweet potatoes (Ipomoea batatas), potatoes (S. tuberosum), corn (Zea mays), sugar cane (Saccharum officinarum), PeruvalliKizhangu (Dioscorea bulbifera), SiruvalliKizhangu (Dioscorea alata), Kottaimudhirnthaavarai (L. purpureus), Pazhayapuli (Tamarindus indica). Fruits: grapes (Vitis vinifera), banana (Musa × paradisiaca), water melon (Citrullus lanatus), Paereetchu (P. dactylifera), Sitreechu (P. sylvestris), Palapazham (Artocarpus heterophyllus). Animal product: Vaankozhi Kari, KadalkellitruMeeen, KaruvavvalMeen, MattuIraitchi, SemmariyattuIraichi. Nuts and seeds: cashew nuts (Anacardium occidentale). Spices, salty, and sweetness: KarumbuVellam (Saccharum officinarum), UrundaiVellam. Oil: corn oil (Zea mays), soya bean oil (Glycine max). Food: over cooked rice, sweetened food, fried food, alcohol. Drinks: PazhayaIlaneer (Cocos nucifera).

Varmam:[18] BoomiKaalam, PidariVarmam, AamaiKaalam, Udhirakaalam, KozhunduVarmam, AlliVarmam, UllangalVellaiVarmam, VayuKaalam, NaaganapootuVarmam. If obesity present Rt. BoomiKaalam, ManjalVarmam, KaalkavuliVarmam, KaalkarandaikannuVarmam, UrumiKaalam.

Karpam[25]: VembuKarpam, VallaikodiKarpam, AyilpattaiKarpam, PoornaChandrodhayam, AyabringarajaKarpam, KarisalaiKarpam, AsogupattaiKarpam, ArugampulKarpam, InjiKarpam.

Yogam[25]: AttangaYogam: Aiyamam, Nyamam. Asanam: Surya Namaskar 10-step module 12 times twice a day. Standing asanas: Ardhakatisakrasanam, Trikonasanam, Parivritta Trikonasanam. Sitting asanas: Kukudasanam, Ustrasanam, Patchimotasanam, Vekrasanam, Ardhamatsyendrasanam, Seshangasana, Yoga mudra, Matchasanam, Suptavajrasanam. Supine position: Navasanam, Pavanamuktasanam, Halasanam, Sarvangasanam, Viparitakarni. Prone position: Bhujangasanam, Salabhasanam, Dhanurasanam. Relaxing position: Savasanam, Makarasanam, Balasanam. Pranaymam: Naadi Sudhdhi Pranayamam 9–27 rounds 2–4 times a day in empty stomach. Meditation: meditative postures: Padmasanam, Vajrasanam.

External therapies[26]: PodiThimirdhal: It must be done using herbal formulations. Vedhu (Kaal Sutigai) with herbs. Thokkanam and Thadaval Muraigal

[Table 3] represents the single herbs used in the Siddha system of medicine which has a potent anti-diabetic, hypoglycemic activity.
Table 3: Single herbs used for diabetes mellitus

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Financial support and sponsorship

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Conflicts of interest

There are no conflicts of interest.





 
  References Top

1.
Srivastava S, Lal VK, Pant KK. Polyherbal formulations based on Indian medicinal plants as antidiabetic phyto therapeutics. Phytopharmacology 2012;2:1-15.  Back to cited text no. 1
    
2.
Jarald E, Joshi SB, Jain DC. Diabetes and herbal medicines. Iran J Pharmacol Therapeut 2008;7:97-106.  Back to cited text no. 2
    
3.
Mathers CD, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med 2006;3:442.  Back to cited text no. 3
    
4.
Muni Y. Yugi Vaidhya Chinthamani. 1st ed. Chennai: B. Rathina Nayakkar and Sons; 1969. p. 158-160.  Back to cited text no. 4
    
5.
Kuppusamy Mudaliar N. Siddha Maruthuvam Pothu. 1st ed. Chennai: Directorate of Indian Medicine, and Homeopathy; 2004.  Back to cited text no. 5
    
6.
Shanmugavelu M. Noi Naadal Noi Muthal Naadal - 1. IVth ed. Department of Indian Medicine and Homeopathy; 2006.  Back to cited text no. 6
    
7.
Natarajan K, Aanandan AR. Principles of Diagnosis in Siddha. Chennai: Department of Indian Medicine, and Homeopathy; 2009.  Back to cited text no. 7
    
8.
Shanmugavelu M. Noikalukku Siddha Parikaram—Part 2. 3rd ed. Chennai: Dept. of Indian Medicine and Homeopathy; 1999.  Back to cited text no. 8
    
9.
Anonymous. Theran Kudineer-100 (74th stanza). 2nd ed. New Delhi: Central Council for Research in Ayurveda and Siddha.  Back to cited text no. 9
    
10.
Megha Nivarana Pothini Ennum Neerizhivu Maruthuvam. 1st ed. Thamarai Noolagam Chennai; 1998.  Back to cited text no. 10
    
11.
Kannusamy Pillai C. Kannusamiyam Ennum Vaidhya Sekaram. 10th ed. Chennai: B Rathina Nayakkar and Sons; 1991. p. 155-6.  Back to cited text no. 11
    
12.
Kannusamy Pillai S. Pathartha Guna Velakkam (Vegetable Kingdom) by re-edition, Chennai: B. Rathnayakar and Sons; 2017.  Back to cited text no. 12
    
13.
Thiyagarajan R. Siddha Materia Medica (Mineral & Animal section) in Tamil. 1st ed. Chennai: Department of Indian Medicine and Homeopathy; 2008.  Back to cited text no. 13
    
14.
The Siddha Formulary of India, Part-I. 1st ed. New Delhi: Government of India, Ministry of Health and family Welfare, Department of Health; 1992.  Back to cited text no. 14
    
15.
Anonymous. SiddhaVaidhya Thirattu. IInd ed. Department of Indian Medicine and Homeopathy; 2006.  Back to cited text no. 15
    
16.
Thiyagarajan R. Text Book of Materia Medica (Gunapadam). Department of Indian Medicine and Homoeopathy; 2008. p. 12.  Back to cited text no. 16
    
17.
Pillai K. Parambarai Vaidhyam. 9th ed. Chennai: B. Rathna Naayakar & Sons; 2012.  Back to cited text no. 17
    
18.
Kannan Rajaram T. Varma Pullikalin Iruppidam (Location of Varma Points). Munsirai, Kanniyakumari: A.T.S.V.S. Siddha Medical College; 2007.  Back to cited text no. 18
    
19.
The Siddha Formulary of India, Part-II. 1st ed. New Delhi: Government of India, Ministry of Health and Family Welfare, Department of AYUSH; 2011.  Back to cited text no. 19
    
20.
Kannusamippillai Sikitcharathna Deepam Ennum Vaidhya Nool. IInd ed. Chennai: B. Rathnanaayakar & Sons; 2014.  Back to cited text no. 20
    
21.
Thiyagarajan R. A. Anandhan and G. Perumal, Therayar Maha Karisal. Department of Indian Medicine and Homeopathy.  Back to cited text no. 21
    
22.
Durairasan K. Siddha Hygiene and Preventive Medicine. Department of Indian Medicine and Homeopathy; 1993. p. 259.  Back to cited text no. 22
    
23.
Agathiyar Vaithiya Rathina surukkam. 2nd ed. Thamarai Noolagam, Chennai; 1998.  Back to cited text no. 23
    
24.
Pathartha Guna Chintamani. B. Rathnanayakar & Sons; 1965.  Back to cited text no. 24
    
25.
Thiyagarajan R. Siddha Maruthuvam—Sirappu. 3rd ed. Chennai: Department of Indian Medicine and Homeopathy; 2008. p. 3-55.  Back to cited text no. 25
    
26.
Utthamaraayar KS, HPIM. Siddhar Aruvai Maruthuvam. Chennai: Department of Indian Medicine and Homeopathy; 1968.  Back to cited text no. 26
    
27.
Pari L, Murugan P, AppaRao C. Influence of Cassia auriculata flowers on insulin receptors in streptozotocin induced diabetic rats-studies on insulin binding to erythrocytes. Afr J Biochem Res 2007;1:148-55.  Back to cited text no. 27
    
28.
Surana SJ, Gokhale SB, Jadhav RB, Sawant RL, Wadekar JB. Antihyperglycemic activity of various fractions of Cassia auriculata Linn. in alloxan diabetic rats. Indian J Pharm Sci 2008;70:227-9.  Back to cited text no. 28
[PUBMED]  [Full text]  
29.
LukmanulHakkim F, Girija S, Senthil Kumar R, Jalaludeen . Effect of aqueous and ethanol extracts of Cassia auriculata L. flowers on diabetes using alloxan induced diabetic rats. Int J Diabetes Metab 2007;15:100-6.  Back to cited text no. 29
    
30.
Saneja A, Sharma C, Aneja KR, Pahwa R. GymnemaSylvestre (Gurmar): A review. Der Pharmacia Lettre 2010;2:275-84, View at Google Scholar.  Back to cited text no. 30
    
31.
Kanetkar PV, Laddha KS, Kamat MY. Gymnemic acids: A molecular perspective of its action on carbohydrate metabolism. Poster presented at the 16th ICFOST Meet Organized by CFTRI and DFRL, Mysore, India, 2004.  Back to cited text no. 31
    
32.
Sugihara Y, Nojima H, Matsuda H, Murakami T, Yoshikawa M, Kimura I. Antihyperglycemic effects of gymnemic acid IV, a compound derived from Gymnema sylvestre leaves in streptozotocin-diabetic mice. J Asian Nat Prod Res 2000;2:321-7.  Back to cited text no. 32
    
33.
Ratsimamanga A, Loiseau A, Ratsimamanga S. Action of a hypoglycemic agent found in the young bark of Eugenia jambolania [sic] (Myrtaceae) on induced hyperglycemia of the rabbit and continuation of its purification. Comptes Rendus Hebdomadaires des Seances de l’Academie des Sciences D: Sciences Naturelles 1973;277:2219-22.  Back to cited text no. 33
    
34.
Bhaskaran Nair R, Santhakumara G. Antidiabetic activity of the seed kernel Syzygium cumini Linn. Anc Sci Life 1986;6:80-4.  Back to cited text no. 34
    
35.
Ravi K, Sivagnanam K, Subramanian S. Anti-diabetic activity of Eugenia jambolana seed kernels on streptozotocin-induced diabetic rats. J Med Food 2004;7:187-91.  Back to cited text no. 35
    
36.
Renuka C, Ramesh N, Saravanan K. Evaluation of the antidiabetic effect of Trigonella foenum-graecum seed powder on alloxan-induced diabetic albino rats. Int J Pharm Tech Res 2009;1:1580.  Back to cited text no. 36
    
37.
Madar Z, Rachel A, Shlomith S, Joseph A. Glucose lowering effect of fenugreek in noninsulin dependent diabetics. Eur J Clin Nutr 1988;42:51.  Back to cited text no. 37
    
38.
Preet A, Siddiqui MR, Taha A, Badhai J, Hussain ME, Yadava PK, et al. Long-term effect of Trigonella foenum graecum and its combination with sodium orthovanadate in preventing histopathological and biochemical abnormalities in diabetic rat ocular tissues. Mol Cell Biochem 2006;289:137-47.  Back to cited text no. 38
    
39.
Sivakumar V, Dhanarajan MS. Hypoglycemic and antioxidant activity of Tinospora cordifolia in experimental diabetes. IJPSR 2011;2:608-13.  Back to cited text no. 39
    
40.
Rajalakshmi M, Eliza J, Priya CE, Nirmala A, Daisy P. Anti-diabetic properties of Tinospora cordifolia stem extracts on streptozotocin-induced diabetic rats. Afr J Pharmacol 2009;3:171-80.  Back to cited text no. 40
    
41.
Banting FG, Best CH. The internal secretion of the pancreas. J Lab Clin Med 1922;7:465-80.  Back to cited text no. 41
    
42.
Ribnicky DM, Poulev A, Watford M, Cefalu WT, Raskin I. Antihyperglycemic activity of tarralin, an ethanolic extract of Artemisia dracunculus L. Phytomedicine 2006;13:550-7.  Back to cited text no. 42
    
43.
Mythili P, Parameswari CS, Dayana J. Phytochemical analysis of the bark extract of Terminalia arjuna and its cardioprotective effect. 2nd National level Students Conference on Nascent Technologies in Biomedical. Electr Eng Commun (NT- BEECOM’12) 2012;1 S 8:40.  Back to cited text no. 43
    
44.
Mishra A, Garg GP. Antidiabetic activity of fruit pulp of Feronia elephantum Corr. Pharmacogn J 2011;3:27-32.  Back to cited text no. 44
    
45.
Gupta R, Johri S, Saxena A. Effect of ethanolic extract of Feronia elephantum Correa fruits on blood glucose levels in normal and streptozotocin-induced diabetic rats. Nat Prod Rediance 2009;8:32-6.  Back to cited text no. 45
    
46.
Dhasarathan P, Theriappan P. Evaluation of anti-diabetic activity of Strychonous potatorum in alloxan induced diabetic rats. J Med Med Sci 2011;2:670-4.  Back to cited text no. 46
    
47.
Biswas A, Chatterjee S, Chowdhury R, Sen S, Sarkar D, Chatterjee M, et al. Antidiabetic effect of seeds of Strychnos potatorum Linn. in a streptozotocin-induced model of diabetes. Acta Poloniae Pharmaceutica 2012;69:939-43.  Back to cited text no. 47
    
48.
Stohs SJ, Ray S. Anti-diabetic and anti-hyper lipidemic effects and safety of Salacia reticulata and related species. Phytother Res 2015;29:986-95. PMC. Web. September 10, 2018.  Back to cited text no. 48
    
49.
Kataoka K. The hypoglycemic potential and safety profile of Salacia reticulate Wight extract powder in healthy and diabetic subjects. New Diet Ther 2006;20:47-53.  Back to cited text no. 49
    
50.
Yoshino K, Kanetaka T, Koga K. Antioxidant activity of Salacia plant (Salacia reticulata). Food Hyg Saf Sci (Shokuhin Eiseigaku Zasshi) 2015;56:144-50.  Back to cited text no. 50
    
51.
Attanayake A, Jayatilaka K. Anti-diabetic potential of ivy gourd (Coccinia grandis, family: Cucurbitaceae) grown in Sri Lanka: A review Dr. AP Attanayake, KAPW Jayatilaka and LKB Mudduwa. J Pharmacogn Phytochem 2016;286:286-9.  Back to cited text no. 51
    
52.
Manjula S, Ragavan B. Hypoglycemic and hypolipidemic effect of Coccinia indica Wight &Arn in alloxan induced diabetic rats. Anc Sci Life 2007;27:34-7.  Back to cited text no. 52
    
53.
Doss A, Dhanabalan R. Anti-hyperglycemic and insulin release effects of Coccinia grandis (L.) Voigt leaves in normal and alloxan diabetic rats. Ethno Botan Leaflets 2008;12:1172-5.  Back to cited text no. 53
    


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Abstract
Introduction
CLASSIFICATION O...
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Pharmacological ...
PROCEDURE 1
PROCEDURE 2
Siddha Treatment...
Classification o...
Invesigations (<...
Non-Pharmacologi...
Diet—to Add
Treatment Plan (...
Management Of
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