| REVIEW ARTICLE |
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| Year : 2020 | Volume
: 3
| Issue : 3 | Page : 8-18 |
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Viral induced Pediatric Acute Respiratory Distress Syndrome (PARDS) and Siddha Herbs: A Narrative Review
G Kiruthiga, Eugene Wilson, P Sathiyarajeswaran, K Kanakavalli
Central Council for Research in Siddha, Ministry of AYUSH, Govt. of India, Arumbakkam, Chennai 600 106, India
Correspondence Address:
G Kiruthiga
Central Council for Research in Siddha, Ministry of AYUSH, Govt. of India, Arumbakkam, Chennai 600 106
India
 Source of Support: None, Conflict of Interest: None
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Introduction: Pediatric Acute Respiratory Distress Syndrome (PARDS) with acute pulmonary inflammation is one of the leading causes of death within pediatric intensive care unit. Although the mortality rate has reduced with the advent of lung protective ventilation and Extra Corporeal Membrane Oxygenation (ECMO), no specific effective pharmacological treatment is available. This study aims to explore and substantiate the anti-viral potential of Siddha herbs for PARDS. Methods: Thorough survey of research studies from electronic databases and literature analysis of the Siddha texts was performed. The Symptomatology of acute respiratory distress syndrome is comparable to Vichinna Swasam described in Siddha pathology. Results: The viral induced primary pneumonia, the predominant cause of PARDS, could be managed by the use of anti-viral Siddha herbs, known to have inhibitive effects on the cytokine storm in viral progressive states. Various experimental studies that analyze the anti-inflammatory activity of Siddha herbs and their mechanism of action in attenuation or reversal of the acute lung injury caused by pro- inflammatory mediators have been tabulated. Conclusion: The consolidation of experiment knowledge with ethnopharmacological evidence of Siddha plants-based drugs can offer a novel platform for development of integrated anti-viral treatment modules for treating PARDS.
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