| REVIEW ARTICLE |
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| Year : 2020 | Volume
: 3
| Issue : 3 | Page : 28-33 |
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Metal - based Nanoparticle Siddha Formulations for the Management of Emerging Infectious Diseases (EIDs)
K Samraj1, K Nandhagopal1, S Thillaivanan2, A Silambarasan3
1 Siddha Clinical Research Unit, (CCRS, Ministry of AYUSH, Govt. of India), Tirupati, Andhra Pradesh - 517 507, India
2 Govt. of Tamil Nadu, Gudiyattam, Tamil Nadu, India
3 Velumailu Siddha Medical College, Sriperumpudur, Kancheepuram - 602 105, Tamil Nadu, India
Correspondence Address:
K Samraj
Siddha Clinical Research Unit, (CCRS, Ministry of AYUSH, Govt. of India), Tirupati, Andhra Pradesh - 517 507
India
 Source of Support: None, Conflict of Interest: None
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Background: Emerging Infectious Diseases (EIDs) are infections are rapidly increasing in incidence or geographic range; includes previously unrecognized diseases such as AIDS, severe acute respiratory syndrome (SARS), ebola-haemorrhagic fever, nipah virus encephalitis, dengue fever and recent COVID-19 pandemic. Most pathogens involved in EID events are drug-resistant bacteria (54.3%), but virus constitute only 25.4% of EID events, in contrast to previous analyses which suggest that 37–44% of emerging pathogens are viruses and 10–30% bacteria. Metal-based nanoparticles accounts for their considerable interaction with bio molecules within the cell and on the cell surface. These unique properties make metal nanoparticles potential therapeutics for the treatment of infectious diseases Method: In Siddha system of medicine, Ulogankal (metals) are eleven in numbers; they are Thangam (gold), Velli (silver), Sembu (copper), Naagam (zinc), Ehgu (steel), Irumbu (iron), Pithalai (brass), Thara (alloy of copper and lead), Karuvangam (lead) and Velvangam (tin). This review focuses about the antimicrobial, anti-viral, anti-bacterial and immunomodulatory activities of metal-based nanoparticles (NPs) which were already quoted in the Siddha system of medicine. Result: Metal nanoparticles have sufficient physico-chemical properties and surface charges. This review revealed that the metal-based medicines have considerable potential to manage and to provide prophylactic support to the EIDs due to immune enhancing, anti-viral, antibacterial, anti-microbial properties. Conclusion: Nanoparticles utilization is “double-edged sword” providing positive advantages for usefulness and negative impacts on health upon exposure. So, the manufacture authentications, Specific guidelines for metal drugs handling for clinical practice, Novel Drug Delivery System (NDDS), research rationales are essential for the metal based Siddha Medicines (Parpam, Chenduram and Chunnam) in this infection emerging period.
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