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SHORT COMMUNICATION
Year : 2019  |  Volume : 2  |  Issue : 2  |  Page : 58-61

Study on Acute Toxicity of Anti-Flatulent Siddha Formulation Kattu Maantha Kudineer in Swiss Albino Rats


Noinaadal Department, JSA College of Siddha and Research Institute, Pali, Ulundurpet, Tamilnadu, 606104, India

Correspondence Address:
M K Tamil Muhil
Noinaadal Department, JSA College of Siddha and Research Institute, Pali, Ulundurpet, Tamilnadu, 606104
India
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Source of Support: None, Conflict of Interest: None


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Background: The Siddha system of Medicine deals with various branches, one among the branch was Kuzhanthai Maruthuvam which deals with numerous pediatric diseases. Functional dyspepsia is a major health problem in all over the world among childrens. Objective: To study the acute toxicity of Siddha formulation kattumaanthakudineer in swiss albino rats. Methods: The kattumaanthakudineer is prepared and administrated at the dosage of 2000 mg/kg. Healthy swiss albino rats (3 females) of 200-240 g of body weight were selected and allowed for an acclimation period of 7 days. The animals were fasted before the treatment. All animals were treated with 2000 mg/kg signs of toxicity were observed for every one hour for first 24 hours and every day for about 14 days from the beginning of the study. The test substance was administered orally. Results: Single dose oral administration of kattumaanthakudineer at 2000mg/kg caused no adverse toxic effects. The animals did not show any changes in body respiration, urination, defecation, locomotion, salivation, body weight. Conclusion: The acute oral LD50 of test substance in swiss albino rats was observed to be greater than 2000mg/kg. This indicates the safety of kattumaanthakudineer through oral administration.


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