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Year : 2019  |  Volume : 2  |  Issue : 2  |  Page : 54-57

In Vitro Investigation of Antidiabetic Potential of Traditional Herb Passiflora edulis Sims

College of pharmacy, Sri RamachandraInstitute of Higher Education, Porur, Chennai-600116, India

Correspondence Address:
R Varsha Rani
College of pharmacy, Sri RamachandraInstitute of Higher Education, Porur, Chennai-600116
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Source of Support: None, Conflict of Interest: None

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Background: Diabetes Mellitus, currently a Global epidemic affects the quality of the lives of millions. Beside prescribed medication, several herbal drugs are popularly taken as supplements and there is a lot of scientific attention on folklore herbs used in diabetes. The current study is focused at evaluating the antidiabetic potential of Passiflora edulis, through an in vitro investigation, a potential herb in the diabetic management. Methods: Hydro alcoholic extract of powdered leaves of P. edulis were subjected to phytochemical screening and assessed for glucose uptake in vitro in yeast cell model. Results: At a concentration of 5mg/ml, there has been 83.4% uptake of glucose by yeast cells mediated by the extract. There has been 46.5% glucose uptake by yeast cells at lowest tested concentration of 1mg/ml. Yeast cell represents an excellent in vitro system for assessing the trans membrane uptake of glucose, they also mimic glucose utilization by peripheral tissues in vivo. Conclusion: The results have demonstrated significant enhancement of glucose uptake by yeast cells brought about by the extract of leaves of P. edulis. The findings being significant, the leaves of P. edulis may be developed as a highly potent health supplement in diabetic management.

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