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Year : 2019  |  Volume : 2  |  Issue : 2  |  Page : 3-10

A Review on Pharmacological Approach of the Therapeutic Property of Madhuca longifolia (J.Koenig ex L.) J. f. Macbr. Flower

Post graduate and Research Department of Foods and Nutrition, Ethiraj College for Women, Chennai-600 008, India

Correspondence Address:
A Bibha Mishra
Post graduate and Research Department of Foods and Nutrition, Ethiraj College for Women, Chennai-600 008
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Source of Support: None, Conflict of Interest: None

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Liver plays an important role in maintaining the metabolic function and excretion of toxins from the body. An injury or liver dysfunction caused by consumption of toxic chemicals, excessive alcohol and microbes result in a challenging condition called hepatotoxicity. Madhuca longifolia belonging to Sapotaceae family is found to possess pharmacological properties in the treatment of various diseases. The present review aims at compiling the hepatoprotective effect of Mahua flower based on various experimental studies. Methanolic extract of Mahua flower exhibited hepatoprotective property when administered at different dosages in rat was found to lower the levels of SGPT, SGOT, ALP and total bilirubin simultaneously increasing serum total proteins and albumin. The ethanolic extract also showed hepatoprotective activity against paracetamol induced hepatotoxicity in albino rats when administered in dosage of 500 and 750 mg/kg body weight by stimulating the healing and regeneration of hepatocytes. Hepatoprotective activity might be due to the effect of extractsagainst the cellular leakage and loss of function of the cell membrane in hepatocytes. The protective effect might be due to the presence of alkaloids, flavonoids and phenolics. Future prospects include purification and characterization of phyto-compounds present in the Madhucalongifolia flower. Further studies on mechanism of action will lead to discovery of novel therapeutic agents for the treatment hepatic diseases.

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