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Year : 2019  |  Volume : 2  |  Issue : 2  |  Page : 36-41

Anti-Proliferative Activity of Green Synthesized Silver Nanoparticles (AgNPs) from a Siddha Medicinal Plant Enicostema axillare (Poir. ex Lam.) A.Raynal

School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, 613401, India

Correspondence Address:
V Vadivel
School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, 613401
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Source of Support: None, Conflict of Interest: None

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INTRODUCTION: Silver nanoparticles (AgNPs) have attracted more attention of the researchers due to its distinctive chemical, physical and biological properties. In the present study, a Siddha medicinal plant Enicostema axillare (Family: Gentianaceae, Tamil: Vellarugu) was used to synthesize AgNPs through green route and their anti-proliferative activity was studied in cell line model. MATERIALS AND METHODS: Green synthesized AgNPs using Enicostema axillare extract was characterized using UV, TEM, XRD and zeta potential techniques and also evaluated for their anti-proliferative activity in DLA cell line model. RESULTS: Among different solvents, methanol extract of Enicostema axillare was contained high total phenolic concentration (5412 mg GAE / L), and hence it was used to synthesize AgNPs. Formation of AgNPs was confirmed by UV absorption (443 nm) while TEM results indicated the spherical shape and diameter of AgNPs (10.93 - 13.95 nm). Results of zeta potential (-13.5 mV) showed the stability of hydrated AgNPs and the XRD and FT-IR data indicated the crystalline nature and presence of extract as capping agent, respectively. Green synthesized AgNPs showed remarkable anti-proliferative activity against the DLA cell line (74 %, IC-50 value 0.053 mg/ml). CONCLUSION: The Siddha plant Enicostema axillare could be explored to synthesis AgNPs by green route with remarkable anti-proliferative property.

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